The Best Resveratrol
The Best Resveratrol
Optimized Resveratrol
Findings from published scientific literature indicate that resveratrol may be the most effective plant extract for maintaining optimal health and promoting longevity.114 Resveratrol is a phytoalexin, a natural plant antibiotic which is produced by Vitis vinifera as a response to attack by molds. Because of the widespread use of pesticides in modern wine-making, including the practice of copper sulphation, the level of resveratrol in modern wines has plummeted. Red wine contains resveratrol, but the quantity varies depending on where the grapes are grown, the time of harvest and other factors. In fact, usually only one to three mg of resveratrol per liter of red wine is currently found, even in the most robust red wines. After years of relentless research, a standardized resveratrol extract is now available as a dietary supplement.
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"Scientists have identified a substitute to red wine called Resveratrol that they believe might do more than just protect the heart but could, in very high concentration, significantly extend life by preventing a number of age-related illnesses."
Optimized Resveratrol
250 mg, 60 vegetarian capsules
Research funded by the Life Extension Foundation showed that a combination of low-dose (20 mg) resveratrol plus grapeseed extract mimicked many of the favorable gene expression changes seen in calorie-restricted animals. Other studies, however, indicate that higher doses may be needed to obtain all of resveratrol’s positive benefits including promoting healthy insulin sensitivity, enhanced mitochondrial function, reduced expression of inflammatory factors, and protection against the toxic effects of a high-fat diet.
Life Extension has evaluated the published studies on resveratrol to establish the doses humans might need to take to duplicate the remarkable laboratory findings. The results of Life Extension’s analysis yield a wide range of potentially effective doses: from 20 to 250 mg a day and higher. The resveratrol potency you choose may be based on your current state of health and/or your desire to reach the upper limits of a healthy human life span. Life Extension offers Optimized Resveratrol, a supplement that contains 250 mg of standardized trans-resveratrol for those who want optimal potencies.
Supplement Facts
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Serving Size 1 vegetarian capsule |
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Servings Per Container 60 |
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| Amount Per Serving | |
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Trans-resveratrol [from red grape & vine (Vitis vinifera) and Polygonum cuspidatum (root) extract] |
250 mg |
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Red Grape (Full Spectrum French Red Wine Polyphenol Profile), Grape Vine (Vitis vinifera), Wild Blueberry (Vaccinium angustifolium), and Polygonum cuspidatum extract blend [supplying polyphenols, anthocyanins, OPCs, free resveratrol, resveratrol conjugates (epsilon-viniferin, trans and cis-polydatin), and resveratrol analogs (pterostilbene)] |
85 mg |
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Quercetin (as Quercetin dihydrate) |
60 mg |
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Other ingredients: silica, magnesium stearate, vegetable cellulose (capsule). |
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Contains corn. This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives. |
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Dosage and Use
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Take one capsule daily with or without food, or as recommended by a healthcare practitioner. |
Caution
Cell culture studies suggest that resveratrol is a weak inhibitor of the liver metabolism system P450 3A4, but this interaction is of unknown significance in humans. Ingestion of large amounts of resveratrol may increase blood levels of drugs known to be metabolized via CYP3A4. This would include statins, calcium channel blockers, certain immunosuppressant drugs (e.g. cyclosporine), and drugs for erectile dysfunction (e.g. sildenafil). Caution is advised if used concurrently with anticoagulants or antiplatelet drugs such as Clopidogrel (Plavix®).
Warnings
- Keep out of reach of children.
- Do not exceed recommended dose.
- Do not purchase if outer seal is broken or damaged.
- If you have a bad reaction discontinue use of product immediately.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Resveratrol May Help Protect Against Alzheimer's
A study published in Journal of Biological Chemistry has shown that resveratrol, a compound found in grapes, red wine, peanuts and berries, lowers the levels of the amyloid-beta peptides, which cause much of the neurological damage associated with Alzheimer's disease. Researchers administered resveratrol to cells which produce human amyloid-beta and tested the compound's effectiveness by analyzing amyloid-beta levels inside and outside the cells. They found that amyloid-beta levels in the treated cells were much lower than those in untreated cells. It is thought that resveratrol acts by stimulating the degradation of these amyloid-beta peptides.
Although more research is needed, early results suggest that this natural compound may have a therapeutic potential in Alzheimer's disease. Resveratrol is currently being researched for a potential role in fighting other human amyloid-related diseases, including Huntington's, Parkinson's and prion diseases.
J. Biol. Chem. Vol. 280; Issue 45: 37377-37382, 11-11-05.
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